JHU-Funded Research Combating Effect of Tobacco Use

Airway Diseases

Effects Of Cigarette Smoke On Airway Epithelial Barrier Function
PI: Venkataramana Sidhaye, MD

The Effects Of Secondhand Tobacco Smoke On Cystic Fibrosis
PI: Garry R. Cutting, MD

Smoke-Induced Dysregulation Of Airway Aquaporins
PI: Landon S. King, MD

Cancer: Chemotherapeutic Agents

The Role Of Cdk5 In Cancer And Metastasis
PI: Barry Nelkin, PhD

Functional Role Of Cdc91l1-Containing Complex In Human Bladder Cancers
PI: Edward Ratovitski, PhD

Hedgehog Signaling Links to Cancer and Injury Repair in Bladder Epithelium
PI: Sunil Karhadkar, MBBS

Genetic And Epigenetic Alterations In Bladder Cancer By Tobacco Smoke
PI: Mohammad O. Hoque, DDS, PhD

The Effect Of Adenylate Kinase 3 On Tobacco Smoke-Induced Cisplatin Resistance In Bladder Cells
PI: Aditi Chatterjee, PhD

Adenoviral Bladder Cancer Gene Therapy
PI: Ronald Rodriguez, MD, PhD

A Marker For Bladder Cancer In Involuntary Smokers
PI: Robert H. Getzenberg, PhD

Activation Of Ddx3 By Benzo[A]Pyrene Diol Epoxide, A Component Of Second Hand Tobacco Smoke In Transformation Of Human Breast Cells: A Potential Mechanism For Neoplastic Transformation
PI: Venu Raman, PhD

Estrogen Receptor Signaling in Normal and Cancerous Breast Epithelial Cells
PI: Ben Park, MD, PhD

Activation of CUBGP1 in Breast by Secondhand Tobacco Smoke
PI: Cynthia Zahnow, PhD

Second Hand Smoke And Its Role In Breast Cancer
PI: Cynthia Zahnow, PhD

Promoter Hypermethylation as a Molecular Marker for Breast Cancer
PI: PI: Hetty Carraway, MD

HDGF, A New Potential Target For Breast Cancer Therapy
PI: Jun Yang, PhD

 Second Hand Tobacco Smoke And Hmg-Iy In Breast Cancer
PI: Francescopaolo Di Cello, PhD

Role of WT1 in the Pathogenesis of Breast Cancer
PI: David Loeb, MD, PhD

Novel Drug Development for Breast Cancer
PI: Saeed Khan, MS, PhD

Cancer: Cervical

Development of Novel Human Immunology Assays for Human HPV Vaccine Trials
PI: Chien-Fu Hung, PhD

Cancer: Gastric

Gastric Cancer: Molecular Pathogenesis And Biomarker Discovery
PI: Florin M. Selaru, MD

Cancer: Head and Neck

Epigenetic Alterations In Progression Of Esophogeal Squamous Cell Carcinoma By Tobacco Smoking
PI: Myoung Sook Kim, PhD

 Tobacco-Induced Mitochondrial Alterations In Upper Aerodigestive Mucosa
PI: Joseph A. Califano, MD

Role of EGRF and Its Downstream Targets in Head and Neck Cancers of Smoking Patients
PI: Alexey Fomenkov, PhD

Cancer: Kidney

Completed Research

Tumor Vaccine After Nonmyeloablative Allogeneic Stem Cell Transplantation for Kidney Cancer
PI: Ephraim Fuchs, MD

Cancer: Lung

Lung Cancer Susceptability and Chemotherapy
PI: Shyam Biswal, PhD

Regulation of Non-small Cell Lung Cancer by Notch
PI: Douglas Ball, MD

Developing NRF2 Inhibitors For Cancer Chemotherapy
PI: Anju Singh, PhD

Using Novel Tumor Models And Novel Therapeutics To Define Tumor Progenitors In Small Lung Cancer
PI: Christine L. Hann, MD, PhD

Targeting Epigenetic Changes In Metastatic Lung Cancer
PI: Rosalyn Juergens, MD

Hedgehog Signaling In Small Cell Lung Cancer Stem Cells
PI: Craig D. Peacock, PhD

Allelic Imbalance And MiRNa Regulation By Tobacco Smoke In Nsclc
PI: Shahnaz Begum, Mbbs, PhD

Small Molecule Inhibitors of Bcl2 as Novel Therapeutics for Lung Cancer
PI: Charles Rudin, MD, PhD

Cyclopamine as Inhibitor of Hedgehog Signaling and Growth in Lung Cancer Cells
PI: Neil Watkins, PhD

Role of HMG-I/Y in the Pathogenesis of Lung Cancer
PI: Raka Bhattacharya, PhD

Cancer: Lymphoma

Functional Analysis Of The MMSET Oncogene In Translocation 4;14 Multiple Myeloma
PI: Josh Lauring, MD, PhD

Cancer: Multiple

Roles of Checkpoint Kinases in the Responses of Human Cancer Cells to DNA Damage
PI: Fred Bunz, MD, PhD

Targeting The Atr Kinase In Second Hand Tobacco Smoke-Related Cancers
PI: Fred Bunz, MD, PhD

Cancers Related To Second Hand Tobacco Smoke
PI: Ben Park, MD, PhD

Regulation Of TGF Beta Signaling In Prostate Cancer
PI: Paula J. Hurley, PhD

Completed Research
Inhibitors Of Histone Acetyltransferase (HAT) As Novel Therapies For HPV-Associated Malignancies
PI: Rhoda Alani, MD

Cancer: Prostate

Inhibition Of Hedgehog Signaling By Cyclopamine Prodrug For Prostate Cancer
PI: Anirban Maitra, MBBS

NDRG1 Modulation To Decrease Prostate Cancer Invasion
PI: Sushant K. Kachhap, PhD

Cancer: Thyroid

Completed Research
BRAF Mutation and Other Common Genetic and Epigenetic Alterations in Thyroid Cancer and the Relationship with Smoking and Clinical Applications
PI: Michael Xing, MD, PhD

Cardiovascular

Role Of Heat Shock Protein 90 In Tobacco Smoke-Induced Heart Disease
PI: Kathleen L. Gabrielson, DVM, PhD

Chronic Onbstructive Pulmonary Disease

Current Research Targeting NRF2 For Intervening Emphysema
Shyam Biswal, PhDM

Neuropilin-1 And Emphysema
PI: Patrice M. Becker, MD

Role Of Cyclic Guanosine Monophosphate In Tobacco Smoke-Induced Lung Endothelial Dysfunction And Emphysema
PI: David B. Pearse, MD

Matrix-Induced Epithelial Activation In Bronchitis
PI: Maureen Horton, MD

Diagnostic Techniques

The Macronome As A Tool For Early Cancer Diagnosis
PI: Samuel R. Denmeade, MD

Disease Prevention

Prevention Of Tobacco-Related Disease
PI: Stephen P. Teret, JD, MPH

Exposure to Second Hand Tobacco Smoke

Chronic Cigarette Smoke Extract Treatment Selects For Apoptotic Dysfunction And Mitochondrial Mutations In Minimally Transformed Oral Keratinocytes
PI: Joseph A. Califano, MD

Second Hand Tobacco Smoke Exposure Among Bar And Nightclub Employees
PI: Ana Navas-Acien, MD, PhD

Neurobehavioral Consequences of Tobacco Exposure

Second Hand Tobacco Smoke And Thyroid Disease
PI: Rachel Ying Vun Chong, MD

Pregnancy and Perinatal Effects from Tobacco Smoke Exposure

Second-Hand Tobacco Smoke And Neonates And Predisposition To COPD And Durable Effects Of Newborn Cigarette Smoke Exposure On The Adult Lung
PI: Sharon A. Mcgrath-Morrow, MD

Tobacco Smoke Exposure, Innate Immunity, And Chronic Sinusitis
PI: Andrew P. Lane, MD

Epithelium and Immunomodulation in Chronic Rhinosinusitis
PI: Jean Kim, MD, PhD

Molecular Mechanisms of Spatiotemporal Regulation of Leukocyte Chemotaxis and its Dysregulation Involved in Chronic Sinusitis
PI: Jin Zhang, PhD